Doctor's Best Benfotiamine with BenfoPure 300mg (Vitamin B1 Derivative) 60 Vegetarian Capsules

Benfotiamine (S-benzoylthiamine-O-monophosphate) is a synthetic thiamine derivative (vitamin B1) belonging to a family of compounds called allithiamines. Benfotiamine is fat soluble, more bioavailable and physiologically active than thiamine. Benfotiamine helps to maintain healthy cells in the presence of glucose in the blood, provides support in the fight against oxidative stress and supports healthy aging.


Benfotiamine increases blood levels of thiamine pyrophosphate (TPP), the biologically active thiamine coenzyme, and stimulates transketolase, a cellular enzyme necessary to maintain normal glucose metabolic pathways. Benfotiamine can significantly improve the condition of thiamine, especially when compared to the usual forms of thiamine. In a randomized, double-blind, crossover study comparing the bioavailability of benfotiamine with the bioavailability of thiamine mononitrate (the most common form of vitamin B1 supplementation) in 12 subjects, benfotiamine increased blood thiamine levels on average 5 times greater than thiamine mononitrate, while increasing thiamine levels in red blood cells. Benfotiamine is converted to S-benzoylthiamine (by removing O-monophosphate via the gastrointestinal tract) which readily passes through the intestinal cells and is converted into thiamine.


Benfotiamine is fat soluble, more bioavailable and physiologically active than thiamine. Benfotiamine helps to maintain healthy cells in the presence of glucose in the blood, provides support in the fight against oxidative stress and supports healthy aging. Benfotiamine helps maintain healthy glucose metabolism by increasing levels of thiamine pyrophosphate (TPP) in blood and tissues, a biologically active form of the thiamine coenzyme. TPP acts as a coenzyme for three key enzymes involved in glucose metabolism: 1) transsketolase, 2) pyruvate dehydrogenase, and 3 ) α-ketogutarate decarboxylase. The last two enzymes are involved in using glucose as fuel. Consequently, TTP is essential to supply the cell with energy.