LIFE EXTENSION SAMe S-Adenosyl-Methionine 400mg 30 Enteric Tablets

 

• It helps to maintain a stable mood
• Helps maintain liver health
• It helps maintain healthy joint function

SAMe helps maintain a stable mood and joint function without side effects. In addition, SAMe has multiple mechanisms of action that are used throughout the body, especially the liver, to help maintain the health of the liver. Largely known for its effects on optimal mood, SAMe has also shown benefits for the liver, brain, and joints.

Life Extension first introduced SAMe (S-adenosyl methionine) in 1997, and scientists continue to discover the impressive benefits of this versatile nutrient.

SAMe is an amino acid derivative normally synthesized in the body that can become depleted with disease or age. The supplementation of SAMe plus folic acid, trimethylglycine (TMG or betaine), vitamins B6 and B12 seems to be an effective way to overcome this deficiency.

SAMe is concentrated in the liver and brain and is the main methyl donor in the synthesis of hormones, nucleic acids, proteins and phospholipids, as well as catecholamines and other neurotransmitters. SAMe is required for the synthesis of norepinephrine, dopamine and serotonin. SAMe facilitates the use of glutathione, which improves the body's antioxidant defenses. It also helps to maintain the level of acetylcholine which is essential for cognitive functions.

SAMe is used by the body in three important pathways:

• Methylation (introduction of methyl groups to activate certain molecules)
• Polyamine synthesis (for cell growth, gene expression, neuron regeneration, etc.)
• Trans-sulfuration (synthesis of cysteine, glutathione and other sulfate compounds)
• In 2002, an agency of the US Department of Health and Human Services conducted a meticulous evaluation of SAMe. His findings demonstrate the effectiveness of SAMe in maintaining a stable mood and joint function without any side effects. As aging people often suffer from joint discomfort and immobility, SAMe solves many of the problems that people grapple with as they age.

SAMe has multimodal mechanisms of action that are used throughout the body, especially the liver. In order to fulfill its detoxifying role, the liver continually performs a large number of complex enzyme reactions. SAMe facilitates the healthy enzymatic processes of methylation and increases the level of glutathione in the liver, a critical antioxidant. When liver function is compromised, glutathione is depleted, leading to free radical damage. In addition, SAMe acts as a methyl donor in the synthesis and formation of phosphatidylcholine and L-cysteine, necessary for the maintenance of liver health.

Recent studies from Harvard Medical School and Massachusetts General Hospital show the benefits of SAMe for mood enhancement. In addition, a report published in Germany indicates that SAMe may help maintain healthy neurological functions. The report revealed that:

SAMe increased the level of glutathione by 50% and the activity of the enzyme glutathione by 115%.
SAMe reduced the free radical activity measurement by 46%.
SAMe inhibited lipid peroxidation by 55% in culture.

SAMe's ability to increase brain cell methylation facilitates DNA's youthful enzymatic activity, which may help explain the mood-enhancing properties of SAMe. These enzymatic reactions are necessary for the healthy conversion of neurotransmitters such as serotonin and dopamine.